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Cohort Acronym

Cohort type
Neurodegenerative disease-specific cohort

Alzheimer's disease, Mild cognitive impairment (MCI), Vascular dementia

Participant type
No diagnosis

Recruitment Period 1985-2017 
Sample size at start or planned sample size if still recruiting 3,000  
Estimated Current Sample Size  
Age at Recruitment > 60   
Gender Male and Female 

A population-based prospective study of cerebro-cardiovascular diseases was begun in 1961 in the town of Hisayama, a suburb of the Fukuoka metropolitan area of Kyushu Island in Japan. In addition, comprehensive surveys of cognitive impairment in the elderly of this town have been conducted since 1985. In 1988, a total of 1,228 residents aged ?60 years (91.1% of the total population in this age group) participated in a screening examination for the present study. After exclusion of 33 subjects who had dementia, 90 who had already had breakfast, 5 who were on insulin therapy, and 81 who could not complete the OGTT, a total of 1,019 subjects without dementia underwent the OGTT. From a total of 1,019 subjects, 2 who died before starting follow-up were excluded, and the remaining 1,017 subjects (437 men and 580 women) were enrolled in this study.

The subjects were followed up prospectively for 15 years, from December 1988 to November 2003 (mean 10.9 years; SD 4.1 years).

Country Japan 
Contact details
Institution name Kyushu University 
Principal Investiator (PI) Professor Toshiharu Ninomiya 
Contact phone number  
Address Department of Epidemiology and Public Health,
Graduate School of Medical Sciences,
Kyushu University Fukuoka,
Funders (Core support) The Ministry of Education, Culture, Sports, Science and Technology of Japan, Ministry of Health, Labour and Welfare of Japan 

Variables Collected

Brain related measures: N/A
Funtional rating: Individual physiological
Anthropometric: Blood pressure, Height, Waist circumference, Weight
Physical: Cardiovascular, Respiratory
Biological samples: Blood
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: Consent for brain donation
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Occupation and employment
Health service utilisation: N/A
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