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Cohort Acronym

Cohort type
Neurodegenerative disease-specific cohort

Alzheimer's disease, Lewy body disease, Mild cognitive impairment (MCI), Subjective memory complaints (SMC) or subjective cognitive decline (SCD)

Participant type
Condition diagnosed

Recruitment Period 2005 
Sample size at start or planned sample size if still recruiting 265  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment >60   
Gender Male and Female 

Dementia with Lewy Bodies (DLB) is the second most common cause of neurodegenerative dementia in older people. The aim of LewyPro is to examine and characterise symptoms and brain changes during the prodromal period of LBD. Earlier diagnosis is important because it facilitates care planning, leads to earlier treatment of cognitive symptoms and enables earlier identification of other symptoms, including parkinsonism.

Lewy Pro is recruiting a group of people with mild cognitive impairment (MCI) and prodromal symptoms suggestive of Dementia with Lewy Bodies (DLB) and following them up annually to assess biomarker changes and clinical course. The initial assessment will include a detailed clinical assessment, a blood sample, a lumbar puncture for cerebrospinal fluid, and a DaTSCAN.

Last Update 21/09/2017

Country United Kingdom 
Contact details
Institution name Newcastle University 
Principal Investiator (PI) Professor Alan Thomas 
Contact email PI Email: [email protected]  
Contact phone number +44 (0) 231912081322 
Address Biomedical Research Building,
Newcastle University Campus for Ageing and Vitality,
Newcastle upon Tyne,
NE4 5PL 
Funders (Core support) National Institute for Health Research (NIHR)|Newcastle Biomedical Research Unit|National Health Service (NHS)|Foundation Trust, Newcastle University|Alzheimer's Research UK 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Weight
Physical: Cardiovascular, Hearing and Vision
Biological samples: Blood, Cerebral spinal fluid (CSF), CSF biomarker data available
Genotyping: Gene screening
Brain imaging: Single photon emission computerised tomography (SPECT)
Brain banking: Consent for brain donation
Lifestyle: Alcohol, Smoking
Socio-economic: Education, Family circumstances, Housing and accommodation, Income and finances, Informal support, Occupation and employment
Health service utilisation: N/A
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