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Cohort Acronym

Cohort type
General population-based cohort

Dementia (unclassified), Other NDs not listed

Participant type
No diagnosis

Recruitment Period 2006-2013 
Sample size at start or planned sample size if still recruiting 12706  
Estimated Current Sample Size 10,000 to 19,999 
Age at Recruitment 65-93   
Gender Male and Female 

The Lifelines Cohort Study is a large population-based cohort study and biobank that was established as a resource for research on complex interactions between environmental, phenotypic and genomic factors in the development of chronic diseases and healthy ageing. The Lifelines cohort distinguishes a children’s cohort (aged 0-18), an adult cohort (aged 18-65) and the elderly cohort (aged 65+). The protocol for these three sub-cohorts is largely the same, but focuses in part on the characteristics of the specific participant groups.

Between 2006 and 2013, inhabitants of the northern part of The Netherlands and their families were invited to participate, thereby contributing to a three-generation design. Follow-up visits are scheduled every 5 years, and in between participants receive follow-up questionnaires. Linkage is being established with medical registries and environmental data. Lifelines contains information on biochemistry, medical history, psychosocial characteristics, lifestyle and more. Genomic data are available including genome-wide genetic data of 15638 participants. Fasting blood and 24-h urine samples are processed on the day of collection and stored at -80 °C in a fully automated storage facility. The aim of Lifelines is to be a resource for the national and international scientific community. Requests for data and biomaterials can be submitted to the Lifelines Research Office ([email protected]).

Country Netherlands 
Contact details
Institution name Lifelines Cohort Study and Biobank 
Principal Investiator (PI) Dr Aafje Dotinga 
Contact email PI Email: [email protected] or [email protected]  
Contact phone number  
Address Lifelines Cohort Study and Biobank,
PO Box 30.001,
9713 BZ Groningen,
The Netherlands 
Funders (Core support) Dutch Government, Organization of Scientific Research NWO, the Northern Netherlands Collaboration of Provinces (SNN), the European fund for regional development, Dutch Ministry of Economic Affairs, Provinces of Groningen and Drenthe, the University of Groningen, and the University Medical Center Groningen. 

Variables Collected

Brain related measures: N/A
Funtional rating: Caregiver, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Musculoskeletal, Reproductive, Respiratory
Biological samples: Blood, Microbiome, Other, Urine
Genotyping: Gene screening
Brain imaging: N/A
Brain banking: Consent for brain donation
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Informal support, Marital status, Occupation and employment, Unpaid care
Health service utilisation: Formal health and social care service utilisation including private care
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