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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Mild cognitive impairment (MCI)

Participant type
No diagnosis

Recruitment Period 1983 
Sample size at start or planned sample size if still recruiting 6,342  
Estimated Current Sample Size  
Age at Recruitment 46-92   
Gender Male and Female 

The longitudinal Study of Cognitive Change in Normal Healthy Old Age (LSCC) is a population study including 6,342 healthy residence of Greater Manchester and Newcastle-upon-Tyne aged from 42 to 92 in 1983. Two different batteries of cognitive tests were alternately administered biennially with additional questionnaires and Dna sample collection until 2003. The aims of the study were to:

• to determine sources of variations in rates of cognitive change between individuals
• to identify factors that slow or accelerate cognitive ageing and that prolong mental productivity or accelerate decline
• to generate and test functional models for the processes of biological ageing, especially of ageing of the brain and the central nervous system
• to test whether the neurophysiological and consequent cognitive changes differ in idiosyncratic patterns between individuals

Country United Kingdom 
Contact details
Institution name University of Manchester 
Website http://www.tandfonline.com/doi/abs/10.1080/13825580490511116 
Principal Investiator (PI) Patrick Rabbitt 
Contact email [email protected] 
Contact phone number  
Address University of Manchester
Age and Cognitive Performance Research Centre
Oxford Road
M13 9PL
Funders (Core support) U.K. Social Science Research Council (1983 to 1988), Medical Research Council (MRC), Economic and Social Research Council (ESRC) 

Variables Collected

Brain related measures: N/A
Funtional rating: Individual physiological, Individual psychological
Anthropometric: N/A
Physical: N/A
Biological samples: Blood, Saliva, Urine
Genotyping: N/A
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Informal support, Marital status, Occupation and employment
Health service utilisation: N/A
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