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Cohort Acronym

Cohort type
Neurodegenerative disease-specific cohort

Alzheimer's disease, Dementia (unclassified), Frontotemporal dementia, Lewy body disease, Mild cognitive impairment (MCI), Other NDs not listed, Parkinson's disease

Participant type
Condition diagnosed

Recruitment Period 2013-17 
Sample size at start or planned sample size if still recruiting 145+  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment >50   
Gender Male and Female 

The NIMROD (Neuroimaging of Inflammation in Memory and Other Disorders) study aims to understand the role of inflammation in several forms of dementia, memory loss and depression (Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), progressive supranuclear palsy (PSP), frontotemporal dementia (FTD), late life depression (LLD), mild cognitive impairment (MCI)). It also aims to understand the changes in the immune system, from immune cells and other components in the blood and cerebrospinal fluid.

To achieve this, NIMROD looks at brain changes in dementia, depression and related disorders in several different ways, detecting differences in brain structure and function, measuring inflammation and annual psychology and memory assessments. A further aim is to investigate if neuroinflammation can predict subsequent clinical course, including cognitive and functional decline.

Last update – 01/02/2017

Country United Kingdom 
Contact details
Institution name University of Cambridge 
Principal Investiator (PI) Professor John O'Brien 
Contact email Email: [email protected] 
Contact phone number +44 (0)1223 768003 
Address Robert Arnold,
Department of Psychiatry,
University of Cambridge,
Herchel Smith Building,
Robinson Way,
CB2 0SZ 
Funders (Core support) NIHR Biomedical Research Unit in Dementia (BRU) 

Variables Collected

Brain related measures: Cognitive function, Mental health, Neurological
Funtional rating: Caregiver, Individual physiological, Individual psychological
Anthropometric: N/A
Physical: Cardiovascular
Biological samples: Blood, Cerebral spinal fluid (CSF), CSF biomarker data available
Genotyping: N/A
Brain imaging: Magnetic resonance imaging (MRI), Positron emission tomography (PET) - amyloid
Brain banking: Consent for brain donation
Lifestyle: Alcohol, Physical activity, Smoking
Socio-economic: Education, Housing and accommodation, Occupation and employment
Health service utilisation: N/A
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