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Cohort Acronym

Cohort type
General population-based cohort

Mild cognitive impairment (MCI), Motor neurone disease, Parkinson's disease, Subjective memory complaints (SMC) or subjective cognitive decline (SCD)

Participant type
No diagnosis

Recruitment Period 1976 
Sample size at start or planned sample size if still recruiting 121,700  
Estimated Current Sample Size 50,000 to 99,999 
Age at Recruitment 30-55   
Gender Female 

The Nurses’ Health Study is a longitudinal population study aimed initially to examine the relation between the use of oral contraceptives, cigarette smoking, and risk of major illnesses in women, mainly cancer and cardiovascular diseases. Since then, the study broadened to include the evaluation of health consequences of many lifestyle practices, including diet, physical activity, and specific forms of hormone therapy.

The participants are registered nurses, aged 30 to 55 years and married at the time of recruitment in 1976, and who lived in the 11 most populous states (California, Connecticut, Florida, Maryland, Massachusetts, Michigan, New Jersey, New York, Ohio, Pennsylvania and Texas).

Country USA 
Contact details
Institution name Brigham and Women’s Hospital and Harvard Medical School 
Principal Investiator (PI) Francine Grodstein and Meir Stampfer 
Contact phone number 617-525-2279 
Address Nurses' Health Study
Channing Division of Network Medicine
181 Longwood Avenue
Boston, MA 02115 
Funders (Core support) National Institute of Health (NIH), National Institute for Occupational Safety and Health (NIOSH) and the Breast Cancer Foundation 

Variables Collected

Brain related measures: N/A
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Musculoskeletal, Reproductive, Respiratory
Biological samples: Blood, Saliva, Urine
Genotyping: N/A
Brain imaging: N/A
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Informal support, Martial status, Occupation and employment, Unpaid care
Health service utilisation: Formal health and social care service utilisation including private care
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