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Cohort Acronym

Cohort type
Neurodegenerative disease-specific cohort

Alzheimer's disease, Dementia (unclassified), Frontotemporal dementia, Subjective memory complaints (SMC) or subjective cognitive decline (SCD), Vascular dementia

Participant type
At-risk diagnosis

Recruitment Period 2014-present 
Sample size at start or planned sample size if still recruiting 650  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment 40-59   
Gender Male and Female 

The PREVENT Research Programme has established a cohort of individuals to explore differences in the brain and cognitive function in healthy people in mid-life (aged 40-59). People are grouped into high, mid and low risk based on their family history and APOE status (a well-known risk gene for Alzheimer’s disease).

650 participants are assessed on biological indicators including markers in blood, saliva, urine and spinal fluid as well as direct imaging of the brain’s structure and function. Changes in all of these markers will be monitored at 2 years to work out if risks that predict these changes. One of the main aims of the study is to identify the earliest signs of changes in the brain whilst people are still in good health.

Last update – 13/12/2017

Country United Kingdom 
Contact details
Institution name University of Edinburgh 
Principal Investiator (PI) Professor Craig Ritchie 
Contact email [email protected] 
Contact phone number +44 (0) 20 8483 1823 
Address Katie Wells
PREVENT Research Programme
West London Cognitive Disorders Treatment and Research Unit
Imperial College London
Lakeside Mental Health Unit
West Middlesex Hospital site
Twickenham Road
TW7 6FY 
Funders (Core support) Alzheimer's Society
Fidelity and Alzheimer's Association 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Respiratory
Biological samples: Blood, Cerebral spinal fluid (CSF), CSF biomarker data available, Saliva, Urine
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI), Magnetic resonance spectroscopy (MRS)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Smoking
Socio-economic: Education, Ethnic group, Housing and accommodation, Income and finances, Marital status, Occupation and employment
Health service utilisation: N/A
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