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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Frontotemporal dementia, Huntington's disease, Lewy body disease, Mild cognitive impairment (MCI), Motor neurone disease, Other NDs not listed, Parkinson's disease, Prion disease, Spinal muscular atrophy (SMA), Spinocerebellar ataxia (SCA), Subjective memory complaints (SMC) or subjective cognitive decline (SCD), Vascular dementia

Participant type
At-risk diagnosis

Recruitment Period 1999-2001; 2013-2014 
Sample size at start or planned sample size if still recruiting 2,103  
Estimated Current Sample Size  
Age at Recruitment 49-88   
Gender Female 

The Prospective Epidemiological Risk Factor (PERF) Study is an ambidirectional population-based study of postmenopausal women set up with the purpose of obtaining a better understanding of the aetiology and pathogenesis of age-related diseases. Participants were recruited from a source population of 8875 women residing in Denmark. The baseline examination (PERF I) comprised 5855 women with mean age of 70.8 years (49.7-88.8) and took place between 1999 and 2001. All subjects have been followed up with registry linkage using population-based national registries. Further, a subcohort was re-invited to attend a follow-up visit between 2013 and 2014 (PERF II). Registry data are available for all baseline participants. From the baseline population, 2103 were enrolled in PERF II.

Country Denmark 
Contact details
Institution name Nordic Bioscience 
Principal Investiator (PI) Dr Cecilie Liv Bager and Morten Karsdal 
Contact email [email protected]; PI Email: [email protected] 
Contact phone number  
Address Nordic Bioscience A/S,
Herlev Hovedgade 207,
DK-2730 Herlev,
Funders (Core support) Danish Research Foundation 

Variables Collected

Brain related measures: N/A
Funtional rating: N/A
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Musculoskeletal, Reproductive, Respiratory
Biological samples: Blood, Urine
Genotyping: Gene screening
Brain imaging: N/A
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Marital status, Occupation and employment
Health service utilisation: Formal health and social care service utilisation including private care
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