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Cohort Acronym

Cohort type
Neurodegenerative disease-specific cohort

Alzheimer's disease, Mild cognitive impairment (MCI)

Participant type
Condition diagnosed

Recruitment Period 2012-2014 
Sample size at start or planned sample size if still recruiting 400  
Estimated Current Sample Size  
Age at Recruitment >18   
Gender Male and Female 

The study is a prospective cohort study that included 400 subjects with MCI enrolled in at Huashan Hospital in Shanghai, China and a followed-up once annually for three years. The objectives are to identify individuals with MCI who convert to AD and to explore factors associated with the conversion. The observation time point is every 12 months and phone interview on 6th, 18th month. The primary endpoint was the time from diagnosis to the conversion from MCI to Probable AD Dementia. The secondary endpoints are the time to conversion from MCI to “Possible AD Dementia” or “Probable AD Dementia”, time to Conversion from MCI to “All-cause Dementia”, Overall survival, Changes in Neuropsychological examinations and Changes in MRI from baseline to the end of follow-up. The planned research duration was from Jan 2012 to Dec 2016.

Country China, Japan 
Contact details
Institution name Foundation for Biomedical Research and Innovation
Fudan University 
Principal Investiator (PI) Professor Bin Zhou 
Contact email [email protected] 
Contact phone number -3039090 
Address Bin Zhou
Translational Research Informatics Center
Foundation for Biomedical Research and Innovation
1-5-4 Minatojimaminamimachi, Chuo-ku, Kobe, Japan 650-0047 
Funders (Core support) The Foundation of Biomedical Research and Innovation 

Variables Collected

Brain related measures: N/A
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Height, Weight
Physical: Cardiovascular, Hearing and Vision
Biological samples: Blood
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Physical activity, Smoking
Socio-economic: Education, Martial status
Health service utilisation: Formal health and social care service utilisation including private care
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