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Cohort Acronym

Cohort type
General population-based cohort


Participant type
No diagnosis

Recruitment Period 1988 
Sample size at start or planned sample size if still recruiting 4859  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment 40-69   
Gender Male and Female 

The Southall And Brent Revisited Study (SABRE) is the largest tri-ethnic population-based cohort in the UK, involving nearly 5000 European, Indian Asian and African Caribbean men and women. It investigates the causes of diabetes and disorders of the heart and circulation and examines underlying reasons for ethnic differences in risk of these disorders.

The participants were aged 40-69 when first studied between 1989 and 1991. In 2008-2011 a comprehensive combined morbidity and mortality follow up was carried out, together with non-invasive clinical measurements in order to quantify sub-clinical disease. SABRE visit 2 tested hypotheses generated from the Southall and Brent baseline studies and ongoing mortality follow-up.

SABRE Visit 3 (25 year follow-up visit) started in July 2014 and is collecting data on index participants and new participants, including partners of index participants. The focus of this visit is on cardiac, cognitive and physical function in older age, in association with mid-life risk factors. Ethnic and gender differences in function will also be examined.

Last update – 10/04/2017

Country United Kingdom 
Contact details
Institution name University College, London 
Principal Investiator (PI) Professor Nish Chaturvedi 
Contact email Email: [email protected]| PI Email: [email protected] 
Contact phone number 02076 799471 
Address UCL Institute of Cardiovascular Science,
Gower Street,
Funders (Core support) Wellcome Trust
British Heart Foundation 

Variables Collected

Brain related measures: Cognitive function, Mental health, Neurological
Funtional rating: Caregiver, Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Musculoskeletal, Respiratory
Biological samples: Blood, Saliva, Urine
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Informal support, Marital status, Occupation and employment, Unpaid care
Health service utilisation: Formal health and social care service utilisation including private care
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