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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Parkinson's disease, Vascular dementia

Participant type
No diagnosis

Recruitment Period 1985-87 
Sample size at start or planned sample size if still recruiting 2166  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment ≥75   
Gender Male and Female 

The Cambridge City over-75s Cohort Study (CC75C) is a long-term follow-up study of a representative population-based sample of older people which started in 1985 from a survey of over 2,600 men and women aged 75 and above. Through a series of interviews and assessments spanning almost three decades they have contributed to one of the largest and longest-running longitudinal observational studies of ageing into older old age.
The initial study targeted all men and women aged 75 or older who were registered within a selection of geographically and socially representative general practices in Cambridge, and achieved a 95% response rate in six of the seven practices. From this original survey of 2610 people, 2166 individuals form the baseline sample for the longitudinal cohort. This group has been followed up through ten surveys, with sub-groups assessed more often. Similarly high response rates amongst participants still alive in their late 80s or 90s, and even amongst centenarians, have built an extensive resource of quantitative and qualitative data contributed by a representative sample of very old people and their relatives.
The focus in later years shifted to quality of life issues of ‘older old’ people near the end of life for which we have been interviewing relatives or carers of surviving members of the cohort all aged 95 or more, as well as these study participants themselves.

Last update: 05/01//2017

Country United Kingdom 
Contact details
Institution name Cambridge Institute of Public Health 
Principal Investiator (PI) Professor Carol Brayne 
Contact email PI Email: [email protected] Study Co-ordinator Email: [email protected] Computer Officer (Emily Zhao) Email: [email protected] 
Contact phone number +44 (0) 1223 330334 
Address Department of Public Health and Primary Care, Cambridge Institute of Public Health, Forvie Site|University of Cambridge School of Clinical Medicine, Box 113 Cambridge Biomedical Campus, Cambridge CB2 0SR, UK 
Funders (Core support) Most recent funders: BMA Foundation for Medical Research, Abbeyfield Research Foundation, National Institute for Health Research CLAHRC and The BUPA Foundation;
For full list of funders over three decades see: http://www.cc75c.group.cam.ac.uk/background/grants/ 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: Individual psychological
Anthropometric: N/A
Physical: Hearing and Vision, Musculoskeletal
Biological samples: Blood, Cerebral spinal fluid (CSF), Other, Saliva
Genotyping: Gene screening
Brain imaging: N/A
Brain banking: Consent for brain donation
Lifestyle: Alcohol, Physical activity, Smoking
Socio-economic: Education, Family circumstances, Housing and accommodation, Informal support, Marital status, Occupation and employment, Unpaid care
Health service utilisation: Formal health and social care service utilisation including private care
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