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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Mild cognitive impairment (MCI), Subjective memory complaints (SMC) or subjective cognitive decline (SCD)

Participant type
No diagnosis

Recruitment Period  
Sample size at start or planned sample size if still recruiting 3327  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment >75   
Gender Male and Female 

The German Study on Ageing, Cognition, and Dementia (AgeCoDe) in primary care patients is an ongoing multicenter prospective study in elderly individuals with a focus on the identification of risk factors and predictors of cognitive decline and dementia.
Between January 1, 2003 and November 30, 2004 a total of 3327 subjects free of dementia at baseline were recruited from general practitioner (GP) registries and assessed with structured clinical interviews and cognitive tests. Since then, participants as well as their proxies were interviewed by trained staff every 1.5 years. In 2016 follow-up 9 was completed.
Main inclusion criteria were ages greater than 75 years, native German language, absence of severe hearing or vision impairments, and residing at home rather than in an institution.
The approval of this study was provided by the local ethics committees of the Universities of Bonn, Hamburg, D’sseldorf, Heidelberg/Mannheim, Leipzig, and Munich. All subjects gave written informed consent before the participation in this study.

Of the 3,327 patients interviewed at baseline, 84.8% (n = 2,820) could be personally interviewed 1.5 years later and 73.9% (n = 2,460) 3 years later. For the vast majority of subjects who could not be personally interviewed, systematic assessments, focusing particularly on dementia, were obtained from GPs, relatives or caregivers.

Last Update 21/09/2017

Country Germany 
Contact details
Institution name Central Institute of Mental Health, Mannheim, Germany 
Principal Investiator (PI) Dr Siegfried Weyerer 
Contact email Email: [email protected]  
Contact phone number  
Funders (Core support) German Federal Ministry of Education and Research 

Variables Collected

Brain related measures: Cognitive function, Mental health, Neurological
Funtional rating: Individual psychological
Anthropometric: N/A
Physical: N/A
Biological samples: Blood
Genotyping: Gene screening
Brain imaging: N/A
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Housing and accommodation
Health service utilisation: N/A
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