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Cohort Acronym

Cohort type
General population-based cohort


Participant type
No diagnosis

Recruitment Period 1999 
Sample size at start or planned sample size if still recruiting 1,232  
Estimated Current Sample Size  
Age at Recruitment >22   
Gender Male and Female 

The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The cohort was a representative sample of 1,232 participants born between 1974 and 1978 in the hospital of Limache. The study includes data collected at birth, during the 1st year of life, at 22 to 28 years (collected between 2000 and 2002) and at 32 to 38 years (collected between 2010 and 2012).

This was possible because details were collected for all births in the country including duration of gestation, birthweight and birth length. Limache, a semirural agricultural area relatively near Santiago and close to Viña del Mar and Valparaíso, was chosen because: a birth register in the hospital has been kept since the 1970s; paediatric clinical records were kept in the local hospital ; and there was demographic information that emigration from this area was low so that we would be able to find most participants born in the 1970s still living in Limache and in Olmué, a neighbouring area.

Country Chile 
Contact details
Institution name University of Chile 
Principal Investiator (PI) Hugo Amigo, Patricia Bustos 
Contact email PI Email (Chile): [email protected]; [email protected]; PI Email (Kings College London): [email protected] 
Contact phone number Tel: +56 2 2978 6213 
Address Department of Nutrition,
Faculty of Medicine,
University of Chile,
Independencia 1027
Funders (Core support) Wellcome Trust, National Research Fund of Chile 

Variables Collected

Brain related measures: N/A
Funtional rating: N/A
Anthropometric: Blood pressure, Height, Waist circumference, Weight
Physical: Cardiovascular, Respiratory
Biological samples: Blood
Genotyping: N/A
Brain imaging: N/A
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Family circumstances, Housing and accommodation, Income and finances, Informal support, Occupation and employment
Health service utilisation: N/A
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