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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Huntington's disease, Mild cognitive impairment (MCI), Parkinson's disease, Subjective memory complaints (SMC) or subjective cognitive decline (SCD)

Participant type
No diagnosis

Recruitment Period 1995-present 
Sample size at start or planned sample size if still recruiting  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment 40-119   
Gender Male and Female 

Convenience sample of centenarians, their siblings, offspring, spouses and a control sample consisting of people born around same time as offspring but who do not have parents surviving beyond average life expectancy for their birth cohort. Age range 40-119 years, with ~2500 centenarians in the sample including 600 semi-supercentenarians (ages 105-109) and 200 supercentenarians (ages 110+ years).

We collect the below listed data at enrolment and then collect vital status, hospitalization, changes in meds and diagnoses, cognitive function (TICS) and physical function (IADS, ADL) over the phone, annually. Local subjects are asked to undergo annual detailed cognitive function testing in person with ultimately, brain donation. Blood sample collected at enrolment for DNA, RNA and plasma for biomarkers and storage.

Study is open to collaborations. Please contact Dr. Perls

Country USA 
Contact details
Institution name  
Principal Investiator (PI) Dr Thomas Perls 
Contact email [email protected] ; PI Email: [email protected] 
Contact phone number +1 617-638-6688 Tel US Toll-Free: 888-333-6327 
Address New England Centenarian Study
Section of Geriatrics, Robinson 2400
Boston Medical Center
88 E. Newton Street, Robinson 2400
Boston, MA 02118 
Funders (Core support) National Institute on Aging
The William M. Wood Foundation
The Martin and Paulette Samowitz Family Foundation 

Variables Collected

Brain related measures: N/A
Funtional rating: N/A
Anthropometric: Blood pressure, Height, Weight
Physical: N/A
Biological samples: Blood, Other
Genotyping: Gene screening
Brain imaging: N/A
Brain banking: Consent for brain donation
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Informal support, Martial status, Occupation and employment, Unpaid care
Health service utilisation: Formal health and social care service utilisation including private care
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