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Cohort Acronym

Cohort type
General population-based cohort

Mild cognitive impairment (MCI), Parkinson's disease

Participant type
No diagnosis

Recruitment Period 2014- ongoing 
Sample size at start or planned sample size if still recruiting 5000  
Estimated Current Sample Size 0 to 4,999 
Age at Recruitment >50   
Gender Male and Female 

The PROTECT Study will gather data and support innovative research to improve our understanding of the ageing brain and why people develop dementia.

We know that certain factors such as exercise, smoking and blood pressure affect our risk of dementia, and there is increasing evidence that our genes also play a role.

Participants in PROTECT will provide information about themselves and complete online assessments to measure their abilities such as memory and reasoning. By repeating these assessments each year we will monitor how they change over the study. Participants will also provide a sample of their DNA through a simple at-home kit. PROTECT participants will also have the opportunity to take part in innovative studies to answer crucial questions such as:

  • How do key measures, such as memory, language and reasoning change over time as we age
  • How do our lifestyle choices, including our exercise habits and diet affect our risk of dementia
  • What role do genetics play in the ageing brain? How do they affect how our brain functions and what is their influence on development of dementia?
  • What are the early signs of dementia and how can they be distinguished from normal ageing
  • What approaches can be delivered online to influence the ageing process and the development of dementia?

Last Update 21/09/2017

Country United Kingdom 
Contact details
Institution name King's College London 
Principal Investiator (PI) Professor Clive Ballard 
Contact email Email: [email protected]  
Contact phone number Tel: 0207 848 8183 
Address PROTECT study, Clinical Trials Team
Wolfson Centre for Age-Related Diseases
Guy's Campus
King's College London
London SE1 1UL 
Funders (Core support) NIHR Biomedical Research Unit for dementia 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Mental health, Neurological
Funtional rating: Individual psychological
Anthropometric: Height, Weight
Physical: N/A
Biological samples: Saliva
Genotyping: N/A
Brain imaging: N/A
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Marital status
Health service utilisation: Formal health and social care service utilisation including private care
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