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Cohort Acronym

Cohort type
Neurodegenerative disease-specific cohort

Alzheimer's disease, Frontotemporal dementia, Lewy body disease, Mild cognitive impairment (MCI), Parkinson's disease, Subjective memory complaints (SMC) or subjective cognitive decline (SCD), Vascular dementia

Participant type
Condition diagnosed

Recruitment Period 2009-2014 
Sample size at start or planned sample size if still recruiting 1400  
Estimated Current Sample Size  
Age at Recruitment >60   
Gender Male and Female 

The Swedish BioFINDER Study consists of four cohorts where patients are included prospectively and followed longitudinally (www.biofinder.se). At baseline, these individuals undergo detailed and standardized cognitive, neurological and psychiatric examinations. Plasma, blood, CSF and samples for cell biology studies are collected. Most also have also undergone advanced Magnetic Resonance Imaging, and in many of the non-demented cases Amyloid and Tau positron emission tomography (PET) imaging have also been done.

The subcohorts include:
i) Healthy volunteers. Ca 350 volunteers aged 60-100 years old from the population-based Malm’ EPIC cohort (380 participants as of Feb 2016). Follow-up time: at least 8 years with investigations repeated every second year. In this cohort, appr. 20% is expected to have preclinical AD.
ii) Patients with Mild Cognitive Impairment (MCI) or Subjective Cognitive Decline (SCD). Ca 500 patients with MCI/SCD aged 60-80 years. Follow-up time: at least 6 years with investigations repeated every year. In this cohort, appr. 50% is expected to have prodromal AD.
iii) Patients with different dementia disorders. We include ca 250 dementia cases aged 40-100 years with AD, VaD, DLB, PDD or FTD. Follow-up time: at least 2 years with investigations repeated every year.
IV) Patients with Parkinson’s disease (PD) and PD-related disorders. Ca 300 patients with Parkinson-like symptoms. Follow-up time: at least 6 years with investigations repeated every year.

Last Update 21/09/2017

Country Sweden 
Contact details
Institution name Clinical Memory Research Unit, Lund University 
Principal Investiator (PI) Professor Oskar Hansson 
Contact email Email: [email protected]  
Contact phone number +46 40 33 50 36 
Address SUS,
VO Minnessjukdomar,
Simrisbanv 14/4,
Funders (Core support) The European Research Council|The Swedish Research Council|The Crafoord Foundation|The Swedish Brain Foundation|The Strategic Research Area MultiPark (Multidisciplinary Research in Parkinson's disease) at Lund University|The Sk'ne University Hospital Foundation|The Swedish Alzheimer Association|The Swedish federal government under the ALF agreement|The Swedish Parkinson foundation|The foundation Gamla Tj'narinnor|The Evy and Gunnar Sandberg Foundation|The Olle Engkvist Foundation|The Kockska Foundation for Medical Research 

Variables Collected

Brain related measures: Cognitive function, Mental health, Neurological
Funtional rating: Individual physiological, Individual psychological
Anthropometric: Blood pressure, Height, Weight
Physical: Hearing and Vision, Reproductive
Biological samples: Blood, Cerebral spinal fluid (CSF), CSF biomarker data available, Other
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI), Magnetic resonance spectroscopy (MRS), Positron emission tomography (PET) - amyloid
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Smoking
Socio-economic: Education
Health service utilisation: N/A
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