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Cohort Acronym
3C study

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Mild cognitive impairment (MCI), Subjective memory complaints (SMC) or subjective cognitive decline (SCD), Vascular dementia

Participant type
No diagnosis

Recruitment Period 1999-2000 
Sample size at start or planned sample size if still recruiting 9294  
Estimated Current Sample Size  
Age at Recruitment >65   
Gender Male and Female 

The Three-City Study (3C Study) is a population-based longitudinal study of the relation between vascular diseases and dementia in persons aged 65 years and older. A total of 9,294 participants (3,649 men and 5,645 women) were recruited from three French cities: Bordeaux (2,104), Dijon (4,931) and Montpellier (2,259).

The principal objective is to estimate the risk of dementia (Alzheimer’s disease and other types) that may be attributed to vascular factors.

In follow up 1 and 2 (2001-2004) participants were interviewed and subjected to physical and cognitive testing. In follow up 3 (2005-2012) participants completed a postal questionnaire. The third, fourth, and fith waves of follow-up examinations started in 2006 and finished in 2012. A sixth follow-up is ongoing.

Last update – 03/02/2017

Country France 
Contact details
Institution name University of Bordeaux 
Principal Investiator (PI) Christophe Tzourio|Jean-François Dartigues 
Contact email [email protected] 
Contact phone number  
Address Christophe Tzourio, MD, PhD
Bordeaux Population Health Research Center (BPH),
Inserm U1219,
University of Bordeaux,
33076 Bordeaux France 
Funders (Core support) Medical Research Foundation
Sanofi-Synthelabo company

Variables Collected

Brain related measures: Cognitive function, Mental health, Neurological
Funtional rating: Individual psychological
Anthropometric: Blood pressure, Height, Hip circumference, Waist circumference, Weight
Physical: Cardiovascular, Hearing and Vision, Respiratory
Biological samples: Blood
Genotyping: Gene screening
Brain imaging: Magnetic resonance imaging (MRI)
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Marital status, Occupation and employment
Health service utilisation: Formal health and social care service utilisation including private care
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