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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Frontotemporal dementia, Huntington's disease, Lewy body disease, Mild cognitive impairment (MCI), Motor neurone disease, Other NDs not listed, Parkinson's disease, Prion disease, Spinal muscular atrophy (SMA), Spinocerebellar ataxia (SCA), Vascular dementia

Participant type
No diagnosis

Recruitment Period 1994, 2005 
Sample size at start or planned sample size if still recruiting 14,192  
Estimated Current Sample Size 100,000 to 499,999 
Age at Recruitment 0   
Gender Male and Female 

The Uppsala Birth Cohort Multigeneration Study (UBCoS) started in 2005 when we were first able to combine existing data on a representative and well-defined cohort of 14,192 males and females born in Uppsala from 1915-1929 (the Uppsala Birth Cohort: UBCoS) with information on descendants of the original cohort members obtained from routine registers.

In 2007-2011, the study was further developed by additional data collection in school archives and records from Census 1930 and the period of follow-up was extended till end of year 2009.

The study is unique in investigating intergenerational effects as “forward in time” processes, starting at the beginning of the last century (i.e. well before any of the routine registers were in place). Intergenerational associations can be currently investigated in more than 140,000 study subjects from families spanning up to five generations, including the 14,192 original cohort members, their 22,559 children, 38,771 grandchildren and 25,471 great grandchildren born up to 2009.

Country Sweden 
Contact details
Institution name Karolinska Institutet
Stockholms Universitet 
Principal Investiator (PI) Professor Ilona Koupil 
Contact email [email protected] 
Contact phone number +46 73 572 2932 
Address Centre for Health Equity Studies (CHESS)
Dept Public Health Sciences
Stockholms universitet / Karolinska Institutet
SE - 106 91 Stockholm 
Funders (Core support) Swedish Research Council, Swedish Research Council for Health, Working Life and Welfare, European Commission 

Variables Collected

Brain related measures: N/A
Funtional rating: N/A
Anthropometric: Height, Weight
Physical: N/A
Biological samples: N/A
Genotyping: N/A
Brain imaging: N/A
Brain banking: N/A
Lifestyle: N/A
Socio-economic: Education, Ethnic group, Family circumstances, Income and finances, Martial status, Occupation and employment
Health service utilisation: Formal health and social care service utilisation including private care
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