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Cohort Acronym

Cohort type
General population-based cohort

Alzheimer's disease, Dementia (unclassified), Parkinson's disease

Participant type
No diagnosis

Recruitment Period 1957 
Sample size at start or planned sample size if still recruiting 22334  
Estimated Current Sample Size 5,000 to 9,999 
Age at Recruitment >17   
Gender Male and Female 

The Wisconsin Longitudinal Study (WLS) is a longitudinal population cohort started in 1957, with a questionnaire administered to all Wisconsin High School seniors. In 1964, a randomly selected one-third of the members of the class of 1957 were followed up with a brief questionnaire to parents asking about their child’s post high-school education and occupation. Direct contact with the graduate began with a telephone interview in 1975, and subsequent telephone and mail surveys in 1993 2004. In 1977 a subset of graduate’s siblings were interviewed by phone and in 1995 and 2005 interviews were conducted with one sibling from each family whenever possible. Spouses of Graduates and Siblings who were married at the time of the 2004/2005 interview were also interviewed by phone. Most recently in-person interviews with a leave-behind questionnaire were administered in 2011 to both the graduate and sibling panels. Saliva was collected from both graduate and sibling participants via a mail-effort in 2008 and during the in-person 2011 interview.

Last Update 21/09/2017 

Country USA 
Contact details
Institution name University of Wisconsin-Madison 
Principal Investiator (PI) Dr. Pamela Herd 
Contact email Dr. Carol L Roan email: [email protected] PI email: [email protected] 
Contact phone number (608) 265-6196 
Funders (Core support) University of Wisconsin-Madison
1180 Observatory Drive
Wisconsin, US 

Variables Collected

Brain related measures: Behaviour, Cognitive function, Neurological
Funtional rating: Individual psychological
Anthropometric: Height, Hip circumference, Waist circumference, Weight
Physical: Hearing and Vision, Respiratory
Biological samples: Microbiome, Saliva
Genotyping: Gene screening
Brain imaging: N/A
Brain banking: N/A
Lifestyle: Alcohol, Dietary habits, Physical activity, Smoking
Socio-economic: Education, Ethnic group, Family circumstances, Housing and accommodation, Income and finances, Informal support, Marital status, Occupation and employment, Unpaid care
Health service utilisation: N/A
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