Principal Investigators

    Prof Clive Ballard


    King's College London

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    A Systematic Programme to Develop and Evaluate the Best Candidate Treatments for Repositioning as Therapies for Alzheimer s Disease (SMART-AD).

    Source of funding information

    The Wellcome Trust

    Total sum awarded (Euro)

    € 2,457,619

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    This innovative programme will identify drug candidates for repositioning in Alzheimers Disease (AD). We will compare the transcriptional signature of AD with the signatures of up to 4000 drugs with established safety in man to identify 100 candidates with the most promising therapeutic potential. State of the art gene profiling will be used to determine the ability of the candidates to modify the expression of disease-associated transcripts in hippocampal neurons, with the best 20 drugs going f orward to test for biological efficacy in in-vitro assays for a wide-range of pathogenic mechanisms implicated in AD. The six agents with the most favourable impact will then be evaluated in the best rodent model of AD to obtain the proof-of-principle evidence that would support a clinical program. Importantly assays used will measure a range of key pathological and behavioural outcomes, as well as determining the drugs impact on disease-associated transcriptional changes. Each stage will be ove rseen by an independent expert panel to ensure drug selection is rigorous and appropriate for AD. The overall aim of this programme of research is to identify the best candidate to be taken forward to clinical trial in people with AD.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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