Principal Investigators

    Prof. dr. E.M. Hol


    Netherlands Institute for Neuroscience

    Contact information of lead PI



    Title of project or programme

    Adult neural stem cells from post-mortem human brain: Towards an in vitro model for stimulating neurogenesis in neurodegenerative diseases.

    Source of funding information


    Total sum awarded (Euro)

    € 300,000

    Start date of award


    Total duration of award in years



    Research Abstract

    Our main aim is to find drugable targets in adult human NSCs, which can be stimulated to increase neurogenesis in the SVZ
    and thereby facilitate repair of striatal dysfunction in Parkinson, and validate these targets in novel human cell models.
    Our world-wide unique human adult NSC cultures will disclose novel molecular and cellular information, which is essential to
    develop future therapies based on activating the brain’s own repair capacity. Adult human NCS-lines are currently not available,
    but are required to search for compounds that can stimulate endogenous neurogenesis.
    The proposed approach is not only relevant for Parkinson patients, but also for patients suffering from other neurological
    diseases, such as Huntington disease, in which the medium spiny neurons in the striatum are affected, and for patients
    suffering from stroke. Stimulating endogenous neurogenesis has so far mainly been studied in animals. The application of adult
    human NSC-lines will lead to a replacement, reduction and refinement of animals used to study neurogenesis in several
    neurological disorders. The immortalized human NSCs will be valuable tools for the world-wide research community to screen
    for NSC activating compounds.

    Further information available at:

Types: Investments < €500k
Member States: Netherlands
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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