Principal Investigators

    Stefan Marklund


    Umeå University

    Contact information of lead PI



    Title of project or programme

    ALS is caused by strains of SOD1 prions

    Source of funding information

    The Swedish Brain Foundation/Swedish Research Council

    Total sum awarded (Euro)


    Start date of award


    Total duration of award in years



    Research Abstract

    There is no effective therapy for ALS. More than 15 clinical trials using different drugs have been conducted since the turn of the century, and all have failed. The lack of understanding of the underlying disease mechanisms have no doubt contributed to this miserable result. The ALS model in which hSOD1 variants are expressed in rodents, is the
    neurodegenerative disease model which most faithfully recapitulates the modeled disease in humans. In this model, we here show that the basic disease mechanism is an exponential templated replication of hSOD1 prion strains. This novel insight promises to lead to development of both novel rational therapies and novel diagnostics.

    Further information available at:

Types: Investments < €500k
Member States: Sweden
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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