Name of Fellow

    Dr Simon Little



    Wellcome Trust

    Contact information of fellow


    United Kingdom

    Title of project/programme

    An investigation into the neurocomputational role of brain oscillations in human motor control for health and disease.

    Source of funding information

    Wellcome Trust

    Total sum awarded (Euro)

    € 557,817

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Parkinson's disease & PD-related disorders


    Neurodegen | Parkinson

    Research Abstract

    The role of brain oscillations in health and disease remains undetermined. I aim to understand how oscillations influence the human motor system, contribute to Parkinson’s disease (PD) and can be modulated for therapeutic effect using novel adaptive deep brain stimulation (DBS) techniques. Beta oscillations (12-30Hz) have been proposed to carry movement-relevant information in health and be abnormal in PD. Their precise function however is unknown. I will investigate this by examining the spe cific role of beta oscillations during action selection and execution using high precision magnetoencephalography (MEG) in healthy subjects and electrocorticography (ECoG) in PD. Next, I will causally test these relationships using a technique I have developed that can selectively cancel beta through the precise temporal delivery of DBS. Finally, I will test prolonged disruption of beta in PD to determine how dysfunction in action selection/execution mediates motor symptoms and whether re-tuning the beta network can lead to long-lasting improvements in motor function by reducing excessive cortico-subcortical connectivity. This will validate a novel method for investigating oscillatory neural networks using subcortical stimulation but additionally advance a new principled neurostimulation approach to disease that could be applied to understand and treat a range of neuropsychiatric disorders.

Types: Fellowships
Member States: United Kingdom
Diseases: Parkinson's disease & PD-related disorders
Years: 2016
Database Categories: N/A
Database Tags: N/A

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