Name of Fellow


Dr Alexandra Grubman

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


Anti-inflammatory copper complexes for treatment of Alzheimer's Disease

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 409,526

Start date of award


01/01/16

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


neurodegeneration | metal metabolism | neuroinflammation | alzheimer disease | stem cells

Research Abstract


Brain inflammation and disrupted metabolism of the biologically important metal, copper, play key roles in Alzheimer’s disease (AD) progression. Our team has developed new copper-based therapeutics, but limited knowledge of how they work impedes clinical trials. My recent findings indicate that these drugs potently prevent inflammation. My proposal seeks to understand how copper-complexes reduce damaging inflammatory responses in novel human cell models of AD.

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