Title of study
ASPirin in reducing Events in the Elderly: an RCT of low dose aspirin
Name of Principal Investigator - Title
Name of Principal Investigator - First name
Name of Principal Investigator - Last name
Address of institution -Institution
Address of institution - Street address
Address of institution - City
Address of institution - Postcode
Q1a. Please indicate below if your cohort includes or expects to include, incidence of the following conditions?
Alzheimer's disease and other dementias|Parkinson's disease
Q2a. In a single sentence what is the stated aim of the study? (Maximum 30 words)
To determine whether regular low dose aspirin extends survival free of dementia and persistent physical disability
Q2b. What distinguishes this case-control study from other studies?
This is not a case control study but an RCT over an average of 5 years of treatment
Q3a. i) Number of publications that involve use of your cohort to date
Q3a. ii) Please give up to three examples of studies to date (PI, Institution, Title of Study)
John McNeil, Monash University, Methods and rationale paper for ASPREE|John McNeil, Monash University, Methods and rationale paper for ASPREE|Elsdon Storey, Monash University, Methods and rationale paper for sub-study on neurocognitive function and neuroimaging (ENVISION)
Q3b. If data on research outputs are already available please paste the publication list/other data or provide a link to where these data are publicly available
Q3c. If no research has been done as yet, please explain in a few sentences what information (i.e. research findings) you expect will be gained from the case-control study
The RCT will determine the primary prevention benefits of low dose aspirin in elderly people
Q4a. Study criteria: what is the age range of participants at recruitment? Age in years From:
Q4a. Study criteria: what is the age range of participants at recruitment? To:
Q4b. Study criteria: what are the inclusion criteria?
Able to give informed consent and attend a general practice; aged 70+; either gender; generally 'healthy'
Q4c. Study criteria: what are the exclusion criteria?
History of CVD, dementia, loss of independence, anaemia, very high blood pressure, bleeding risk
Q5a. What is the size of the cohort (i.e. how many participants have enrolled)?
Q5b. What is the expected number of control participants?
Q6a. Please describe what measures are used to characterise participants
Neurocognitive assessments, physical and clinical criteria
Q6b. Are there additional measures for participants with the clinical disorder?
Q6c. Are there defined primary and secondary endpoints (e.g. defined health parameters)?
If YES please specify
death, dementia, persistent physical disability, CVD, stroke, cancer, depression, clinically significant bleeding
Q7. What is the study design?
Randomized Controlled Trial
Q8. Are your cases matched by
Q9a. Does your study includes a specialised subset of control participants?
Q9b. If your study includes a specialised subset of control participants please describe
Q10a. Is data collection for this study
Q10b. If data collection is ongoing, are there plans to continue the cohort study beyond the current projected end date?
Yes - intend to apply for funding
Q11. Are data collected
Only through the study|Through links to medical records|Through links to other records or registers(Cancer and other registries)
Q12. Is there a system in place to enable re-contact with patients for future studies?
Yes (participants have given permission to be re-contacted via the PIs)
Q13a. Please give information on data stored in a database (1)
Data summarised in database
Q13a. Please give information on data stored in a database (2)
Q13a. Please give information on data stored in a database (3)
Q13a. Please give information on data stored in a database (4)
Q13a. Please give information on data stored in a database (5)
Please specify language used
Q13b. Please give information on how data is held as individual records
Q14a. Are data available to other groups?
Q14b. If data is available to other groups what is the access policy/mechanisms for access?
Q15. What data sharing policy is specified as a condition of use?
Data made publicly available after a specified time point
Q16a. Are tissues/samples/DNA available to other groups?
Q16b i) If yes, please describe below
Q16b. ii) In what form are tissues/samples/DNA supplied?
Q16b iii) Is the access policy/mechanism for obtaining samples the same as that for obtaining data (Q14 above)?
Q17. Is information on biological characteristics available to other groups?
Types: Case Control Studies
Member States: Australia
Diseases: Alzheimer's disease & other dementias, Parkinson's disease & PD-related disorders
Database Categories: N/A
Database Tags: N/A
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