Name of Fellow

    Prof David Rubinsztein



    Wellcome Trust

    Contact information of fellow


    United Kingdom

    Title of project/programme

    Autophagy in health and disease.

    Source of funding information

    Wellcome Trust

    Total sum awarded (Euro)

    € 4,542,895

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Neurodegenerative disease in general


    Alzheimer | Cognitive impairment | Dementia | Huntington | Neurodegen | Parkinson

    Research Abstract

    Intracellular protein misfolding/aggregation characterises many late-onset neurodegenerative diseases, including Alzheimer s disease, Parkinson s disease, tauopathies, and Huntington s disease (HD)). The mutations causing HD and many related diseases confer novel toxic functions on the specific protein. Thus, it is important to understand the factors regulating the levels of these proteins. (Macro) autophagy clears long-lived proteins and organelles by forming autophagosomes that engulf p ortions of cytoplasm. Autophagosomes ultimately fuse with lysosomes, where their contents are degraded. Autophagy regulates the levels of intracytoplasmic aggregate-prone proteins that cause neurodegenerative diseases, including HD. Autophagy upregulation may attenuate diseases like HD, and possibly tuberculosis. Autophagy inhibition slows growth of existing tumors, and may also contribute to pathology in various neurodegenerative diseases. I aim to: Discover novel autophagy-modulating dr ugs/pathways and test their clinical relevance in models of neurodegenerative diseases, tuberculosis and cancer. Test if there are beneficial/deleterious effects of constitutive autophagy upregulation in vertebrates. Develop methods to infer autophagic flux in vivo. Understand how autophagy compromise causes pathology. Identify novel autophagy-regulating mechanisms and investigate possible disease relevance. These studies will help the understanding of the relationship betwee n autophagy, normal physiology and disease, and will provide proof-of-principle for autophagy-modulating strategies as therapies for a range of conditions.

Types: Fellowships
Member States: United Kingdom
Diseases: Neurodegenerative disease in general
Years: 2016
Database Categories: N/A
Database Tags: N/A

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