Principal Investigators

    Aubert, Isabelle


    Sunnybrook Research Institute (Toronto, Ontario)

    Contact information of lead PI



    Title of project or programme

    Brain degeneration and regeneration in preclinical models of Alzheimer's disease

    Source of funding information


    Total sum awarded (Euro)

    € 637,850

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    With aging, the risk to develop Alzheimer’s disease increases. Alzheimer’s disease is characterized by deficits in brain functions, which seriously affects daily living. Brain cells are deteriorating and their capacity to survive becomes compromised. This degeneration leads to deficits in critical tasks performed by the brain, such as learning and memory. Our research aims to promote general cell health by providing therapeutics that support cell survival and growth. We propose that these regenerating brain cells will assure adequate cell-to-cell communication and improve learning and memory performances. We propose an innovative treatment that uses magnetic resonance imaging (MRI) and ultrasound technologies to deliver novel therapeutics to targeted areas of the brain. Firstly, brain areas where treatment is required are identified using MRI. Secondly, these selected brain areas are exposed to ultrasounds, through the cranium and without the need for invasive surgery. Thirdly, the therapeutic of interest is injected into the venous system. The effects of ultrasounds on the blood vessels of the brain will allow the therapeutic to leave the blood and enter targeted brain areas, where they are needed to promote cellular survival, repair and regeneration. This non-invasive approach of imaging and ultrasound delivery of regeneration-promoting therapeutics will be tested in preclinical models of Alzheimer’s disease. MRI combined with ultrasound applications are also being developed for the treatment of the human brain. This project has the potential to improve the quality of life for people living with Alzheimer’s disease and other neurodegenerative disorders in the future.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: Canada
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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