Name of Fellow


Prof Ashley Bush

Institution


Funder


NHMRC

Contact information of fellow


Country


Australia

Title of project/programme


Brain metal neurochemistry: mechanism-driven drug discovery for neurodegeneration

Source of funding information


NHMRC

Total sum awarded (Euro)


€ 578,818

Start date of award


01/01/16

Total duration of award in years


5.0

The project/programme is most relevant to:


Alzheimer's disease & other dementias

Keywords


alzheimer disease | metal metabolism | biomarkers | iron | protein biochemistry

Research Abstract


Alzheimer’s disease (AD) is a complex disease where certain proteins congeal in the brain and metals accumulate. This project investigates the function of the proteins in microscopically transporting the metals. It will also look for tests that predict the onset of AD by measuring iron and iron related proteins by using special brain imaging (MRI), and measurements in spinal fluid. Finally, it will test drug candidates that target the metals, in animal models of AD, and in early clinical trials.

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