Principal Investigators

    prof. RNDr. Zden?k Glatz, CSc.


    Masaryk University, Faculty of Science

    Contact information of lead PI


    Czech Republic

    Title of project or programme

    Capillary electrophoresis based high-throughput system for beta-secretase inhibitor screening as a therapeutic target of Alzheimer's disease

    Source of funding information

    Czech Science Foundation

    Total sum awarded (Euro)

    € 222,444

    Start date of award


    Total duration of award in years



    Research Abstract

    The aim of the project is the development of the high-throughput system based on capillary
    electrophoresis for the purpose of beta-secretase inhibitor screening as a potential therapeutic target for
    the Alzheimer’s disease treatment. Whereas the classic off-line assays will be used mainly as supporting
    methods, the main attention will be paid on on-line approaches – Electrophoretically Mediated
    MicroAnalysis and Transverse Diffusion of Laminar Flow Profiles methodologies and IMmobilised Enzyme
    Reactor. They are probably the best candidates for high throughput screening of new drugs because
    their main feature is full automatization combined with very low sample consumption since they use the
    capillary not only as a separation medium but also as a reaction chamber. Incubation of the enzymatic
    reaction, separation of the reaction products and their detection is thus integrated into a single fully
    automated analysis, not only increasing the throughput of the assay but also minimizing the possibility of
    experimental error and the consumption of reactants.

    Further information available at:

Types: Investments < €500k
Member States: Czech Republic
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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