Principal Investigators

    Prof. dr. H.W.G.M. Boddeke


    UMC Groningen

    Contact information of lead PI



    Title of project or programme

    Cell-type specific changes in gene-networks in the human brain: towards a selective Alzheimer therapeutic target

    Source of funding information


    Total sum awarded (Euro)

    € 273,304

    Start date of award


    Total duration of award in years



    Research Abstract

    We aim at identifying gene regulatory networks, based on molecular changes in microglia and astrocytes acutely isolated from post-mortem brains of controls and AD patients. We will start with tissue sampling of post mortem non-demented control and AD brains, and isolation of astrocytes and microglia followed by extraction of RNA. The RNA expression profiles of the different cell-types will be determined using RNA sequencing, which will be performed by our partner Pfizer (in collaboration with the Boddeke and Hol labs), together we will also perform the bioinformatics analysis. The major deliverables of the proposal will contain the most detailed account of molecular changes in glia during AD pathogenesis, novel drug targets, and potential novel biomarkers.

    Further information available at:

Types: Investments < €500k
Member States: Netherlands
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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