Principal Investigators

    Duennwald, Martin L


    University of Western Ontario

    Contact information of lead PI



    Title of project or programme

    Cellular responses to protein misfolding in aging cells

    Source of funding information


    Total sum awarded (Euro)

    € 339,446

    Start date of award


    Total duration of award in years



    Research Abstract

    While advanced age presents the highest risk factor for many neurodegenerative diseases, it remains unclear how aging contributes to these diseases at genetic, cellular, and molecular levels. As an innovative approach, combining transcriptome, genome, and proteome wide studies in chronologically aged yeast cells and sampled from human brains analyzed by computational methods we aim to identify and characterize genetic, cellular, and biochemical networks that modulate protein misfolding in aging cell. Our study will thus provide novel insight into the nexus of protein misfolding and aging and may thus identify new therapeutic targets fro the treatment of these devastating diseases.

    Further information available at:

Types: Investments < €500k
Member States: Canada
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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