Duennwald, Martin L
University of Western Ontario
Cellular responses to protein misfolding in aging cells
While advanced age presents the highest risk factor for many neurodegenerative diseases, it remains unclear how aging contributes to these diseases at genetic, cellular, and molecular levels. As an innovative approach, combining transcriptome, genome, and proteome wide studies in chronologically aged yeast cells and sampled from human brains analyzed by computational methods we aim to identify and characterize genetic, cellular, and biochemical networks that modulate protein misfolding in aging cell. Our study will thus provide novel insight into the nexus of protein misfolding and aging and may thus identify new therapeutic targets fro the treatment of these devastating diseases.