Principal Investigators



    National Institute of Mental Health

    Contact information of lead PI



    Title of project or programme

    Cerebral Protein Synthesis as a Measure of Degenerative Changes in a Transgenic Rat Model of Alzheimers Disease

    Source of funding information

    NIH (NIA)

    Total sum awarded (Euro)


    Start date of award

    Total duration of award in years



    Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Basic Behavioral and Social Science... Behavioral and Social Science... Brain Disorders... Dementia... Mental Health... Neurodegenerative... Neurosciences

    Research Abstract

    During the 2016 funding period, we carried out studies to measure rCPS with the autoradiographic L-1-C-14leucine method in cohorts of WT and TgF344-AD at six, 14, and 18 months of age. In these animals we also measured activity by means of open field behavior, memory by means of the T-maze, olfaction by means of the buried food task, and sleep behavior. In a separate cohort of animals studied longitudinally we measured rCPS with the L-1-C-11leucine PET method. We have completed the behavioral testing and we are in the process of analyzing the results of the rCPS experiments.

    Further information available at:

Types: Investments < €500k
Member States: United States of America
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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