Principal Investigators

    A/Pr Daniel Hatters


    University of Melbourne

    Contact information of lead PI



    Title of project or programme

    Chaperone defenders against toxic clusters in Huntington's disease

    Source of funding information

    National Health and Medical Research Council

    Total sum awarded (Euro)

    € 395,370

    Start date of award


    Total duration of award in years



    Research Abstract

    Huntington disease results from a mutation that causes the Htt protein to become abnormally sticky and form toxic clusters in neurons. Cells have natural defences to clustering with proteins called chaperones, which are exciting therapeutic targets. This project will examine how chaperones defend against toxic Htt clustering with cutting-edge imaging technologies. The knowledge gained will aid in designing therapeutic strategies that stimulate the defence processes and suppress the clusters.

    Further information available at:

Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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