Principal Investigators
A/Pr Daniel Hatters
Institution
University of Melbourne
Contact information of lead PI
Country
Australia
Title of project or programme
Chaperone defenders against toxic clusters in Huntington's disease
Source of funding information
National Health and Medical Research Council
Total sum awarded (Euro)
395,370
Start date of award
01/01/2013
Total duration of award in years
4
Keywords
Research Abstract
Huntington disease results from a mutation that causes the Htt protein to become abnormally sticky and form toxic clusters in neurons. Cells have natural defences to clustering with proteins called chaperones, which are exciting therapeutic targets. This project will examine how chaperones defend against toxic Htt clustering with cutting-edge imaging technologies. The knowledge gained will aid in designing therapeutic strategies that stimulate the defence processes and suppress the clusters.
Further information available at:
Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A