Principal Investigators

    dr. E.M.J. Foncke



    Contact information of lead PI



    Title of project or programme

    CHEVAL-in: neurophysiological determinants of conversion to psychosis and response to cholinesterase inhibitors in Parkinson's disease

    Source of funding information

    Parkinson Vereniging

    Total sum awarded (Euro)

    € 39,609

    Start date of award


    Total duration of award in years



    Research Abstract

    Visual hallucinations (VH) are the most common non-motor symptoms in
    Parkinson’s disease (PD). As an independent predictor for cognitive decline and
    nursing home placement they form an important disability milestone in the
    course of PD. According to current clinical guidelines minor VH do not require
    treatment per se. But as minor VH precede the stage of major VH without insight
    and PD associated psychosis (PDP) they offer an opportunity for early
    intervention. Neuroleptic drugs delay the transition into PDP but are
    unsuitable for early treatment of VH due to their side effects. We hypothesize
    that cholinesterase inhibitors (ChEI) are a well-tolerated alternative for the
    early treatment of minor VH to delay the progression to PDP and that brain
    network analysis is suitable to predict treatment response.

    Objective of the study:
    investigate whether early treatment with ChEI delays the progression of minor
    VH to major VH without insight or PDP. In addition, we will measure motor
    control, psychotic symptoms, cognitive impairment, mood disorders, adverse
    events and compliance, disability, caregiver burden and care use. We assess the
    cost-effectiveness of early chronic treatment of VH with ChEI. Finally, we
    analyse changes of functional brain networks before and during treatment.

    Study design:
    a randomized, double blind, placebo-controlled, multi-center trial with an
    economic evaluation.

    Study population:
    168 patients with PD and VH after fulfilling the in-and exclusion criteria.

    Further information available at:

Types: Investments < €500k
Member States: Netherlands
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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