Principal Investigators




    Contact information of lead PI



    Title of project or programme

    Cognitive Enhancement Through Transcranial Laser Therapy

    Source of funding information

    NIH (NIA)

    Total sum awarded (Euro)


    Start date of award


    Total duration of award in years



    Acquired Cognitive Impairment... Aging... Alzheimer's Disease... Alzheimer's Disease Related Dementias (ADRD)... Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD)... Atherosclerosis... Behavioral and Social Science... Brain Disorders... Cardiovascular... Cerebrovascular... Clinical Research... Clinical Research - Extramural... Clinical Trials and Supportive Activities... Dementia... Neurodegenerative... Neurosciences... Prevention... Translational Research... Vascular Cognitive Impairment/Dementia

    Research Abstract

    ? DESCRIPTION (provided by applicant): Cardiovascular diseases are associated with diminished cognitive function, even in patients without vascular dementia. Considering the high prevalence of these disorders in the United States, and the fact that cognition is the most important determinant of quality of life and functional ability in older age, early interventions t preserve cognitive function in patients at cardiovascular risk are crucial for ensuring the successful aging of our growing elderly population. While an ideal intervention would restore the original cardiovascular status, that is often not possible for a variety of reasons. An alternative approach is to support brain energy production by up-regulating mitochondrial respiration. One highly promising novel intervention is transcranial low-level laser therapy (LLLT) with directional low-power and high-fluence light energy from infrared lasers to stimulate brain energy production. LLLT is safe, non-invasive and therapeutically beneficial, promoting enhancement of energy production, gene expression and prevention of cell death. The goal of this project is to test the efficacy of LLLT to enhance neurocognitive function in middle-aged adults and examine the modulating influences of carotid atherosclerosis. The specific aims will be accomplished in a randomized controlled trial (RCT) by examining cognitive test performance and blood oxygen level-dependent (BOLD) response to a working memory task in middle-aged adults pre- and post- 8-week long intervention of LLLT or placebo. In addition, we will examine if carotid artery intima-media thickness (IMT) moderates the therapeutic effects of LLLT.

    Further information available at:

Types: Investments < €500k
Member States: United States of America
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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