Principal Investigators

    Mgr. Ond?ej Bezdí?ek, Ph.D.


    National institute of mental health

    Contact information of lead PI


    Czech Republic

    Title of project or programme

    Cognitive predictors of neurodegeneration

    Source of funding information

    Czech Science Foundation

    Total sum awarded (Euro)

    € 127,818

    Start date of award


    Total duration of award in years



    Research Abstract

    Results from behavioral studies indicate a general age-related decline in cognition, such as speed of processing, attention, working memory, and free recall. On the other hand, there is age invariance when assessing vocabulary or semantic memory. By using in vivo neuroimaging such as magnetic resonance (MRI), we can tap neural substrates of cognitive aging linking behavior and function. Memory impairment is a more accurate predictor of early Alzheimer?s disease (AD) than atrophy of medial temporal lobe (MTL) on MRI. The goal of the present 3-year longitudinal study is to link long-term cognitive predictors (based on explicit memory tests) and rate of MTL atrophy (the first MRI scan in the first and the second in the third year) to estimate their predictive potential for the conversion of healthy aging (HA) into mild cognitive impairment (MCI) or dementia due to AD. By this design we expect to test the hypothesis that non-invasive and cost-effective cognitive measures and MRI are efficient tools for the estimation of conversion risk of HA into neurodegenerative disease.

    Further information available at:

Types: Investments < €500k
Member States: Czech Republic
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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