Principal Investigators


Klas Kullander

Institution


Uppsala University

Contact information of lead PI


Country


Sweden

Title of project or programme


CONTROL AND MODULATION OF HIPPOCAMPAL OLM INTERNEURONS IN MEMORY FORMATION

Source of funding information


The Swedish Brain Foundation

Total sum awarded (Euro)


€ 108,814

Start date of award


01/07/2015

Total duration of award in years


2.5

Keywords


Research Abstract


Neuronal wiring patterns are specific connections within the nervous system necessary for cognitive processes and behavior. Specific insight into circuit functionality is required to provide further knowledge into neuronal signaling and
their dysfunctions in disease. Conditions in which defective neuronal circuitry may be the underlying cause are represented by psychiatric and neurologic disorders,
such as schizophrenia, depression, and Alzheimer’s.
Selective interference with or ablation of the functionality of aberrant axonal projections or certain neuronal populations has proven efficient to better understand these systems. We here propose to investigate neuronal circuitry and identify
genetic determinants of specific interneuron populations and their function.
Combined with other powerful methods, including electrophysiology, pharmacology, optogenetics and in-vivo recordings, we strive to be a state-of-the art laboratory for interrogation of neuronal microcircuitry. This proposal will analyze contributions from defined populations of interneurons in functions including motor control and memory. It will provide insights into the functionality of local interneurons in the hippocampus that control memory formation. This application
will also address the role of modulatory input to the hippocampus, including the exploration of the novel transporter VAAT. Thus, the approach proposed here will interrogate functionality of circuits that are compromised in in disorders of memory, such as Alzheimer’s Disease and dementia.

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