Principal Investigators

    S.Albertil, D.Kaganovich, S.Carra, Jsterneckert, A.Poletti, N.Dantuma, A.Aguzzi



    Contact information of lead PI



    Title of project or programme

    CureALS: Stress granules and proteostasis in motor neurons: towards a mechanistic understanding of ALS

    Source of funding information


    Total sum awarded (Euro)

    € 1,585,814

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Motor neurone diseases


    Research Abstract

    Amyotrophic lateral sclerosis (ALS) and related motor neuron diseases are among the most devastating age-related disorders, and therapies to treat these diseases are still unavai- lable. In recent years, evidence has been accumulating that ALS is caused or exacerbated by aggregates of proteins and RNAs and a failure of the machinery that controls the beha- vior of these proteins and RNAs. In this project, we will study the molecular causes of motor neuron degeneration, focusing on the role of these RNA/protein aggregates as key mediators of cellular decline. We hypo- thesize that the formation of aberrant RNA/protein aggregates initiates a vicious cycle, which eventually triggers the degeneration of motor neurons and the onset of the first clini- cal symptoms. As an experimental system, we will use motor neurons and glial cells derived from immortalized patient cells, which will offer an unprecedented window into the disease. Our approach will offer definitive insight into the complex causes of motor neuron disorders and will provide a solid basis for diagnostics and therapy development.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Germany, Israel, Italy, JPND, Sweden, Switzerland
Diseases: Motor neurone diseases
Years: 2016
Database Categories: N/A
Database Tags: N/A

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