Principal Investigators

    E.Hedlund, R. Sanchez-Pernaute, S.Corti, C.Graff, R.Sandberg



    Contact information of lead PI



    Title of project or programme

    DAMNDPATHS: Elucidation of common transcriptional targets in vulnerable DopAmine, MotorNeuron and frontotemporal Dementia disease PATHwayS

    Source of funding information

    JPND-Cross Disease

    Total sum awarded (Euro)

    € 797,741

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Motor neurone diseases|Spinal muscular atrophy (SMA)|Neurodegenerative disease in general


    Research Abstract

    Our goal is to identify shared molecular pathways leading to selective neuronal cell death in a group of clinically distinct neurodegenerative diseases. We will start with three devastating motor neuron diseases: amyotrophic lateral sclerosis (ALS), spinal muscular atrophy and spinobulbar muscular atrophy – all characterized by the loss of neurons that control voluntary muscles. Genetic causes of these diseases are different, but the patterns of neuronal degeneration are similar.
    We will use RNA sequencing technology to identify genes that are activated in either vulnerable or degeneration-resistant neurons during disease progression. Targets will be verified in post mortem tissues from ALS patients, as well as Fronto-temporal dementia and Parkinson’s Disease patients, to evaluate cross-disease relevance of the genes. We will then use cellular disease models based on patient-specific neurons from induced pluripotent stem cells, to examine the function of candidate genes in neuronal vulnerability or resistance. Finally, we will examine the ability of selected genes to modify disease progression in vivo in mouse models. We are confident that these complementary approaches will lead us to discover key pathways at a stage of disease that may still be reversible, thus opening new avenues for the development of disease- modifying agents that can alleviate the burden of these devastating diseases.

    Lay Summary

    Further information available at:

Types: Investments > €500k, JPND Projects
Member States: Italy, JPND, Spain, Sweden
Diseases: Motor neurone diseases, Neurodegenerative disease in general, Spinal muscular atrophy (SMA)
Years: 2016
Database Categories: N/A
Database Tags: N/A

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