Name of Fellow

    Prof Peter St George-Hyslop



    Wellcome Trust

    Contact information of fellow


    United Kingdom

    Title of project/programme

    Deciphering the fundamental roles of two proteins involved in neurodegenerative disease.

    Source of funding information

    Wellcome Trust

    Total sum awarded (Euro)

    € 822,891

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Neurodegenerative disease in general



    Research Abstract

    The long term goal of this proposal is to understand the 3-D structure and molecular mechanisms of the presenilin/gamma-secretase complex and of the related signal peptide peptidase family of intramembranous aspartyl proteases. We will define their structure and the mechanisms by which they select, dock and then cleave the transmembrane domains of their substrate proteins in an unusual reaction (regulated intramembranous proteolysis), which appears to be catalysed by two conserved hydrophilic aspartyl residues that are buried within the hydrophobic lipid compartment of the membrane.

Types: Fellowships
Member States: United Kingdom
Diseases: Neurodegenerative disease in general
Years: 2016
Database Categories: N/A
Database Tags: N/A

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