Principal Investigators

    A/Pr Michael Lardelli


    University of Adelaide

    Contact information of lead PI



    Title of project or programme

    Defining the changes in cell biology caused by PRESENILIN truncations associated with different diseases

    Source of funding information

    National Health and Medical Research Council

    Total sum awarded (Euro)

    € 417,334

    Start date of award


    Total duration of award in years



    Research Abstract

    Truncations of the PRESENILIN genes in humans can cause two very different diseases: inherited, early onset Alzheimer’s disease (familial Alzheimer’s disease) and a skin disease named inherited Acne Inversa. One truncation is also involved in the non-inherited, late onset form of Alzheimer’s disease. Why do these different truncations produce different diseases? Investigating this question will teach us more about the molecular bases of these different diseases. This understanding will be required for the development of treatments.

    Further information available at:

Types: Investments < €500k
Member States: Australia
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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