Prof Brett Garner
Defining the mechanisms by which ABCA7 and apoE control Alzheimer's disease risk. Functional characterisation of new therapeutic targets for dementia prevention and treatment.
Alzheimer's disease & other dementias
alzheimer disease | apolipoprotein e | amyloid beta-protein | neurodegeneration | transgenic mouse
Alzheimers disease (AD) is the major cause of dementia and is currently without a curative treatment. An understanding of the pathways that lead to AD is urgently required to develop approaches for treatments. We have discovered new pathways by which proteins called ApoE and ABCA7 control AD. We now aim to define precisely how these proteins work in the brain and use this information to develop therapeutic approaches to treat AD in humans.