Principal Investigators

    Nick Fox


    University College London

    Contact information of lead PI


    United Kingdom

    Title of project or programme

    Determining the causes and consequences of brain amyloidosis, atrophy and cerebrovascular disease

    Source of funding information

    Alzheimer's Research UK

    Total sum awarded (Euro)

    € 2,473,105

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Research Abstract

    Alzheimer’s disease (AD) has a long prodromal phase when pathology accumulates before cognitive decline. Biomarkers including MRI/PET/CSF allow aspects of AD pathology to be quantified in vivo, opening a pre-symptomatic window for disease prevention strategies. It is however unknown:
    (a) which factors influence beta-amyloid deposition, a critical early pathogenic step;
    (b) if individuals accumulating sufficient beta-amyloid will inevitably develop AD should they live long enough and if so what influences when; and
    (c) how beta-amyloid interacts with other pathologies to influence cognitive decline.
    We will capitalise on the unique life-course data of the MRC 1946 birth cohort a representative,intensively studied UK cohort now in their 60s by enrolling 500 study members in a two-time-point (0,24m) study involving MRI and amyloid PET, detailed cognitive testing, wet biomarkers and genotyping.
    We aim to:
    (1) identify pre-symptomatic AD and associated biomarkers;
    (2) investigate life-course and genetic influences on symptom onset and progression; and
    (3) provide a critical evidence base for future trials.
    This work will inform pre-clinical AD therapeutic study design: from inclusion criteria to outcome measures. Risk factors identified may be targets for drug development, and may already be amenable to modification.

    Lay Summary

    Further information available at:

Types: Investments > €500k
Member States: United Kingdom
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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