Principal Investigators


Gauthier, Serge GJia, Jianping

Institution


Douglas Hospital Research Centre (Verdun, Québec)

Contact information of lead PI


Country


Canada

Title of project or programme


Diagnostic Biomarkers for pre-dementia Alzheimer Disease

Source of funding information


CIHR

Total sum awarded (Euro)


€ 650,000

Start date of award


01/01/2013

Total duration of award in years


4.0

The project/programme is most relevant to:


Alzheimer's disease and other dementias

Keywords


alzheimer's disease| csf biomarkers| dementia| early onset familial alzheimer's disease| fluid biomarkers| genetics| imaging biomarkers| mri| pet| protenomics

Research Abstract


Lay Summary


Some persons get Alzheimer’s disease (AD) in young age (before age 65) because of genes inherited from one of their parents. This is called Early Onset Familial Alzheimer Disease (EOFAD). Some of these autosomal dominant genes have been identified, but in half of the families they are still unknown. Persons carrying such genes show changes in their brain chemistry long before they develop symptoms. This study aims at finding as many families as possible in Canada and in China with EOFAD, study which genes are involved in those families, and study the brain chemistry using brain scans, spinal fluid examination, neuropsychological tests over 18 months. This study is important because it will bridge research activities in AD between Canada and China, find missing genes in EOFAD, and establish the sequence of changes in the brain of persons who will get AD symptoms within 10 years.

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