Principal Investigators

    Professor Pippa Tyrrell

    Institution

    University of Manchester

    Contact information of lead PI

    Country

    United Kingdom

    Title of project or programme

    Does subcutaneous interleukin-1 receptor antagonist reduce inflammation after ischaemic stroke compared to placebo?

    Source of funding information

    The Stroke Association

    Total sum awarded (Euro)

    € 277,280

    Start date of award

    01/07/2013

    Total duration of award in years

    3

    Keywords

    Research Abstract

    Thrombolysis and stroke unit care have improved stroke outcomes, but there remains an urgent need to reduce neuronal injury following stroke. The cytokine interleukin-1 (IL-1) mediates brain injury. IL-1 enhances endothelial reactivity and recruitment of circulating inflammatory cells whereas inhibition of IL-1, using IL-1 receptor antagonist (IL-1Ra), markedly reduces experimental brain injury and could be a widely applicable treatment for stroke. We have shown that intravenous IL-1Ra reduces markers of inflammation in blood and cerebrospinal fluid following stroke and subarachnoid haemorrhage; and that IL-1Ra is safe and well tolerated. Subcutaneous IL-1Ra is the form of IL-1Ra that is currently available for clinical use and this route of administration has proved effective experimentally in stroke. It is essential to examine whether SC IL-1Ra reduces inflammation in stroke patients, prior to a full clinical trial.
    We will undertake a single-centre, double-blind, randomised, placebo-controlled Phase II study of IL-1Ra (30 per group), administered SC, twice daily for three days in patients with ischaemic stroke.
    Primary outcome: reduction in concentrations of IL-6 to day 3.
    Secondary clinical outcomes will be collected up to three months. The results will inform a Phase III efficacy study.

    Further information available at:

Types: Investments < €500k
Member States: United Kingdom
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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