Principal Investigators

    Rylett, Jane R


    University of Western Ontario

    Contact information of lead PI



    Title of project or programme

    Effects of Oxidative / Nitrosative Stress and Aging on Cholinergic Neuron Function

    Source of funding information


    Total sum awarded (Euro)

    € 405,262

    Start date of award


    Total duration of award in years



    Research Abstract

    The proposed studies investigate changes that occur in nerve cells due to chemical alterations in the aging brain caused by neurodegeneration, hypertension, blood vessel disease that leads to decreased oxygen and blood flow, or due to stroke. A consequence of these pathological changes is inability of nerve cells to effectively communicate information to fulfill their physiological functions. Cholinergic nerves in brain are particularly susceptible to damage by these pathological conditions, and dysfunction of these nerves can lead to memory loss, dementia, changes in control of blood vessels and blood flow. This could arise if cholinergic neurons are vulnerable to changes in the brain microenvironment that are increased during aging. To illustrate this, amyloid peptide levels increase before cognitive deficits begin and are likely responsible for at least some of the oxidative stress that occurs very early in mild cognitive impariment or in AD.

    Further information available at:

Types: Investments < €500k
Member States: Canada
Diseases: N/A
Years: 2016
Database Categories: N/A
Database Tags: N/A

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