Name of Fellow



    European Commission Horizon 2020

    Contact information of fellow



    Title of project/programme

    Electrophysiological markers of cognitive processes and neuroplasticity in healthy ageing and Alzheimer`s disease

    Source of funding information

    European Commission Horizon 2020

    Total sum awarded (Euro)

    € 180,277

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Ageing | Alzheimer Disease (AD) | Non-invasive brain stimulation (NIBS) | Transcranial magnetic stimulation (TMS) | Electroencephaologram (EEG) | Event-related potentials (ERP).

    Research Abstract

    Ageing of the European population is increasing prevalence of age-related diseases such as Alzheimer’s disease (AD). AD is considered a public health priority due to socio-economic costs and limited efficacy of current pharmacological treatments. Co-registration of electroencephalogram (EEG) and transcranial magnetic stimulation (TMS) is a novelty, non-expensive and non-invasive approach to obtain surrogate markers of cognitive decline. Moreover, repetitive TMS (rTMS) is considered a promising tool to induce neuroplasticity and improve cognitive functions. The main objective of this research is providing markers of brain activity, reactivity, connectivity and plasticity related with healthy and pathological ageing (i.e., early AD). Thus, samples of healthy young, healthy elderly and AD patients will perform a behavioural task (to study visuospatial attention and cognitive control processes) while carrying out EEG recording and online EEG/TMS co-registration. Correlates of brain activity (event-related brain potentials), reactivity (amplitude of TMS evoked potential -TEP) and connectivity (TEP topography, coherence, synchronization, and graph theoretical analysis of complex networks) will be obtained before and after of delivering offline rTMS. It will allow studying differences in cortical responses induced by rTMS on each group of participants, which will provide correlates and biomarkers of brain plasticity related with age and AD. These biomarkers will allow the identification of individuals at early stages of AD and evaluating efficacy of novel TMS treatments. Importantly, identification of rTMS parameters responsible to induce neural plasticity and improve cognitive functions will contribute to develop rehabilitation protocols for AD patients.

Types: Fellowships
Member States: European Commission
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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