Principal Investigators

    Mclaurin, Joanne


    Sunnybrook Research Institute (Toronto, Ontario)

    Contact information of lead PI



    Title of project or programme

    Enhancing vascular remodeling in Alzheimer's disease following covert stroke

    Source of funding information


    Total sum awarded (Euro)

    € 682,561

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease and other dementias


    alzheimer's disease| brain microvascular network| cognitive function| covert stroke| magnetic resonance imaging| neurovascular coupling| two photon microscopy

    Research Abstract

    Lay Summary

    By age 85, one out of every two Canadians will suffer from a stroke, dementia or both. Covert or sub-clinical stroke that typically comprises many small brain vessels yet results in no clinical symptoms is a major risk factor for both overt stroke and dementia. It often develops gradually years before dementia develops, thus offering a window of therapeutic opportunity. Although many therapies have been tried to alter dementia progression, only treatment of midlife hypertension has shown benefit. Meanwhile there are many treatments to reduce stroke risk. There are very few treatment options other than anti-hypertensive drugs to simultaneously lower the risk of both stroke and Alzheimer’s disease, and even fewer are universally available. In this proposal, we will investigate the link between covert stroke and development of Alzheimer’s disease in a mouse model. We will focus on the vascular consequences of stroke that lead to increased risk for Alzheimer’s disease with the ultimate goal of supporting vascular remodeling to prevent cognitive dysfunction.

    Further information available at:

Types: N/A
Member States: Canada
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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