Principal Investigators




    Contact information of lead PI



    Title of project or programme

    Environmental copper exposure and its impact on microglial Abeta clearance

    Source of funding information

    NIH (NIA)

    Total sum awarded (Euro)

    € 2,469,613.76

    Start date of award


    Total duration of award in years


    The project/programme is most relevant to:

    Alzheimer's disease & other dementias


    Abeta clearance, Copper, neuroinflammation, Alzheimer's Disease, Microglia

    Research Abstract

    DESCRIPTION (provided by applicant): Environmental and occupational copper exposure has long been considered one of the environmental risk factors for Alzheimer’s disease (AD). However, the late life impact of the chronic copper (Cu) exposure and its mechanisms of action in the central nervous system (CNS) have not been fully elucidated. While its direct toxicity on neurons and interaction to amyloid-beta (Aß) species are currently been studied, its chronic impact on other non-neuronal cells in the CNS has been overlooked. We hypothesize that a chronic environmentally-relevant Cu exposure impairs the activation of microglial phagocytosis and neuroinflammatory responses, promoting a pathological buildup of Aß species, synaptic loss and cognitive decline. The objective of this study is to determine whether the copper-mediated functional impairment of glial activity promotes neurodegeneration and AD neuropathology in vivo. To achieve our goal, we propose to apply two novel techniques to determine microglia- and astrocyte-specific transcriptome dynamics following chronic Cu exposure in vivo. Our proposed project will uncover the critical pathogenic impact of Cu exposure on microglia, astrocytes and neuroinflammation, and the underlying molecular mechanism by which glial dysfunction leads to the onset and progression of AD in a temporal manner.

    Lay Summary

    PUBLIC HEALTH RELEVANCE: Environmental Cu exposure may increase the risk for Alzheimer’s disease in later life. We will study how chronic environmental Cu exposure triggers Alzheimer’s disease neuropathology, such as amyloid-beta (Aß) plaque deposition, neuronal death and cognitive decline in a mouse model of the disease. Findings from this project will provide key involvement of environmental risk factors on the onset of the disease and potential therapeutic strategies to treat or prevent Alzheimer’s disease among people who are at high risk.

    Further information available at:

Types: Investments > €500k
Member States: United States of America
Diseases: Alzheimer's disease & other dementias
Years: 2016
Database Categories: N/A
Database Tags: N/A

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