Family traits of chronic disease and the missing heritability link. The Malmö Offspring Study (MOS)
Swedish Research Council
Alzheimer's disease & other dementias
The general aim of the study is to map new factors of importance for family traits of chronic disease (diabetes, CVD, COPD, cancer, dementia) in offspring of parents participating in the Malmö Diet Cancer-Cardiovascular (MDC-CV) cohort. These risk factors will include genetics, epigenetics, biomarkers, vascular imaging, family and medical history, lifestyle and social aspects, as well as a 4-day dietary intake registration and also faeces sampling for genetic evaluation of gut bacteria composition (microbiota). A second aim is to link factors in the parents (generation 1) to adverse risk factors, vascular changes, cognitive function and prognosis in the offspring (generations 2 and 3), but also to do the reverse when risk factors in offspring are linked to phenotypes and genotypes in generation 1. A third aim is to use the national Multi-generation register to evaluate the family burden of chronic disease, based on data not only in parents and children but also in siblings and other close relatives. The offspring cohort represents in itself a new cohort for future follow-up. We plan to invite all offspring to index subjects (generation 1, all with full GWAS analysed in 2013) participating in the MDC-CV cohort at baseline (n= 6100) after identification based on official register information (NAVET). We have obtained ethical permission and have started a pilot study in 500 subjects during 2013, aiming for the full-scale study in 2014-2018 with almost 5000 participants.